Osteoporosis is a systemic disorder characterized by decreased bone mass and microarchitectural deterioration of bone tissue, leading to bone fragility and increased susceptibility to fractures of the hip, spine, and wrist.
In respect to this, is osteoporosis a global concern?
As indicated by statistics across Asia, Europe, Latin America and North America (Figure 8), osteoporosis and its associated morbidity is a growing concern worldwide.
Keeping this in consideration, what is pathophysiology of osteoporosis?
Osteoporosis is a metabolic bone disease that, on a cellular level, results from osteoclastic bone resorption not compensated by osteoblastic bone formation. This causes bones to become weak and fragile, thus increasing the risk of fractures.
What is the best and safest treatment for osteoporosis?
Bisphosphonates are usually the first choice for osteoporosis treatment. These include: Alendronate (Fosamax), a weekly pill. Risedronate (Actonel), a weekly or monthly pill.
What is the current research on osteoporosis?
Khosla and other osteoporosis researchers are studying new imaging and computer techniques that will allow them to look inside the bone, and see specific structural characteristics. This will help them to build models of bone strength that can help predict which patients are most likely to have fractures.
What is the epidemiology of osteoporosis?
According to a report by the US Surgeon General 4, approximately 10 million Americans over the age of 50 have osteoporosis, with a further 34 million at risk of the disease. Osteoporotic fractures in the USA are extremely common, with an estimated 1.5 million suffering fragility fractures each year.
What is the infusion for osteoporosis?
Zoledronic acid (ZOL) is an intravenous bisphosphonate that is given once yearly for the treatment of osteoporosis via a medically supervised 15-minute infusion. This ensures compliance for a full 12 months.
What is the main characteristic of osteoporosis?
Osteoporosis causes bones to become weak and brittle — so brittle that a fall or even mild stresses such as bending over or coughing can cause a fracture. Osteoporosis-related fractures most commonly occur in the hip, wrist or spine. Bone is living tissue that is constantly being broken down and replaced.
What is the name of the daily injection for osteoporosis?
TYMLOS is a daily injection for postmenopausal women with osteoporosis. The pen needle is about the length of an eyelash. Each pen has 30 days of medicine. You can take TYMLOS with or without food or drink.
Who osteoporosis category?
Osteoporosis has been operationally defined on the basis of bone mineral density (BMD) assessment. According to the WHO criteria, osteoporosis is defined as a BMD that lies 2.5 standard deviations or more below the average value for young healthy women (a T-score of <-2.5 SD) (1,6).
Why is osteoporosis research important?
Osteoporosis researchers at the UVA School of Medicine have taken a new approach to understanding how our genes determine the strength of our bones, allowing them to identify several genes not previously known to influence bone density and, ultimately, our risk of fracture.