Ehler Danlos syndrome (EDS) as a cause of gastroparesis is not well established in the literature. Prevalence of type III or hypermobility EDS is estimated to be 1 in 5000 people. We report a case of new diagnosis of EDS in a patient with severe gastroparesis.
Hereof, can EDS affect digestive system?
Patients with hypermobile EDS (hEDS) show GI symptoms related to the gut and often meet the criteria for disorders such as indigestion and irritable bowel syndrome. The presence of GI symptoms in EDS patients influences their quality of life.
Keeping this in view, does EDS affect the eyes?
Ophthalmological abnormalities in EDS include but are not limited to myopia, retinal detachment and glaucoma. Some of these can be vision-threatening. An optometrist or ophthalmologist should establish a comprehensive baseline for a person with EDS, including a complete eye exam and history.
Does EDS get worse with age?
Many of the problems associated with EDS are progressive, meaning that they get worse over time.
Does EDS show on MRI?
MRI can help detect lesions in the brain containing collagen fibers, which are often seen in EDS patients who previously experienced trauma.
Does Ehlers Danlos shorten your life?
Patients with the classical and hypermobility forms of Ehlers-Danlos syndrome have a normal life expectancy. About 80% of patients with vascular Ehlers-Danlos syndrome will experience a major health event by age 40 and the life expectancy is shortened, with an average age of death of 48 years.
Does Ehlers-Danlos affect the stomach?
We frequently see patients who mainly have symptoms related to either the upper or the lower digestive tract only, and some research studies have found that a significant proportion of people with hEDS experience some kind of gastrointestinal symptoms.
Does gastroparesis cause malabsorption?
In fact, patients will often show signs of obstruction without a mechanical cause of obstruction. Additionally, they will present with bloating, flatulence, diarrhea, and weight loss due to malabsorption.
Is idiopathic gastroparesis rare?
A rare idiopathic gastroesophageal disease characterized by delayed gastric emptying in the absence of mechanical obstruction of the gastric outlet.
What is the lifespan of someone with EDS?
People affected by vascular EDS have a median life expectancy of 48 years and many will have a major event by age 40. The lifespan of people with the kyphoscoliosis form is also decreased, largely due to the vascular involvement and the potential for restrictive lung disease.
What is the most severe presentation of Ehlers-Danlos syndrome?
SPONDYLODYSPLASTIC EDS results in short stature, joint hypermobility, and intellectual disability. VASCULAR EDS is the most serious type due to the possibility of a shortened lifespan. Minor trauma can lead to extensive bruising and skin tears.
What mimics Ehlers-Danlos syndrome?
Tnxb−/− mice showed progressive skin hyperextensibility, similar to individuals with Ehlers–Danlos syndrome. Biomechanical testing confirmed increased deformability and reduced tensile strength of their skin.
Why does EDS cause constipation?
Any abnormalities in the connective tissues can disrupt how the bowel works leading to motility issues and constipation, plus in extreme cases paralysis of the digestive tract known as ‘gastroparesis’. Sometimes rectal and genital prolapse can occur, which can interfere with the ability to pass a bowel motion.
Will I end up in a wheelchair with EDS?
Some patients with EDS may require specialized mobility devices, such as a wheelchair or a scooter, and a walker, crutches or a cane for mobility. However, care should be taken so that joints and other areas of the body affected by the disease are not injured by shifting weight when, say, walking with a cane or crutch.