Patients need to have a blood test after each dose to confirm that blood calcium level is not abnormally low. Signs of low calcium levels include spasms, twitches or cramps in the muscles; or numbness and tingling in the fingers, toes or around the mouth.
Besides, can Prolia affect blood count?
Low blood calcium (hypocalcemia). Prolia® may lower the calcium levels in your blood. If you have low blood calcium, it may get worse during treatment. Your low blood calcium must be treated before you receive Prolia®.
Also know, can Prolia cause hypercalcemia?
The rebound effect after stopping treatment with denosumab may be associated with rapid loss of the gains in bone mineral density achieved with treatment, high levels of bone remodeling markers, the occurrence of vertebral fractures, and even hypercalcemia.
Can Prolia cause hypocalcemia?
The Prolia® package insert warns that hypocalcemia may be exacerbated by the medication [1]. It advises correction of pre-existing hypocalcemia and close monitoring of calcium, magnesium, and phosphorus within 14 days of injection in those patients predisposed to hypocalcemia and disturbances of mineral metabolism.
Do you have to check calcium before Prolia?
Prolia® may lower the calcium levels in your blood. If you have low blood calcium, it may get worse during treatment. Your low blood calcium must be treated before you receive Prolia®. Take calcium and vitamin D as your doctor tells you to help prevent low blood calcium.
Do you need blood test before Prolia?
Your doctor may do a blood test to check your calcium levels before you use Prolia. Do not use Prolia if you are pregnant or trying to get pregnant. Prolia may harm your unborn baby.
Does Prolia affect white blood cell count?
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Yes, Prolia (denosumab) does appear to weaken your immune system. Research has shown people who take Prolia are at an increased risk of serious infections leading to hospitalizations, including serious infections of the skin, abdominal, urinary tract, and ear.
Does Prolia cause anemia?
anemia, diarrhea, or. skin problems (eczema, blisters, dry skin, peeling, redness, itching, small bumps).
Does Prolia cause low blood pressure?
Symptoms of serious allergic reaction, such as decreased blood pressure and trouble breathing, have been reported in people taking Prolia.
How does Prolia affect blood pressure?
The most common side effects of Prolia® in patients with glucocorticoid-induced osteoporosis are back pain, high blood pressure, lung infection (bronchitis), and headache.
What is a special precaution of denosumab?
Avoid being near people who are sick or have infections while you are receiving this medicine. Check with your doctor right away if you have a fever or chills, red, swollen skin, severe abdominal or stomach pain, or burning or painful urination. Skin problems may occur after receiving Prolia®.
What should I check before denosumab?
The GP should check calcium levels before each dose of denosumab is given. The GP should check calcium levels if suspected signs of hypocalcaemia occur. The GP should contact the Specialist for advice if a patient’s blood test indicate hypocalcaemia or if the patient presents with symptoms of suspected hypocalcaemia.
What should I monitor after Prolia injection?
Periodic monitoring of calcium levels (at the discretion of the prescriber) is recommended after use of denosumab in patients predisposed to hypocalcaemia, including those with severe renal impairment.