The pathophysiological mechanism of peripheral neuropathy in the hypermobility type of EDS appears evident, i.e., hypermobility of joints causes abnormal stretching of or pressure on peripheral nerves, resulting in neuropathy or plexopathy.
Similarly, can EDS be mistaken for fibromyalgia?
The pain is generally complex, often generalized [15], and for people with hypermobile EDS often leads to poor physical, psychosocial, and overall function comparable to patients with fibromyalgia (FM) [16]. As in other chronic pain conditions, psychological symptoms are common both in EDS and HMS [14,17].
Secondly, can Ehlers-Danlos affect the nerves?
Although the nervous system is not considered a primary target of the underlying molecular defect, recently, increasing attention has been posed on neurological manifestations of EDSs, such as musculoskeletal pain, fatigue, headache, muscle weakness and paresthesias.
Can Ehlers-Danlos cause numbness and tingling?
People with hEDS may have neck pain, difficulty walking, numbness and tingling of the hands and feet, dizziness, swallowing difficulties, and changes in speech.
Do Rheumatologists treat Ehlers-Danlos?
The rheumatologist can play an important role in the diagnosis of EDS and is central to the ongoing management of many EDS patients.
Does EDS cause neuropathic pain?
Neuropathic pain and central sensitization. Approximately 68% of chronic pain patients with EDS can be considered to have NP. Compression and axonal neuropathies have been suggested as a potential cause of paresthesia, numbness, and dysesthesia in EDS patients.
Does EDS cause poor circulation?
If you have Ehlers-Danlos syndrome (EDS), you may experience periods of poor blood flow to your fingers and toes that turn them white or blue. These episodes are known as Raynaud’s phenomenon.
Does Ehlers-Danlos show up on MRI?
Apart from a physical examination, skin biopsies, and genetic testing, imaging tests such as X-rays, computerized tomography (CT), and magnetic resonance imaging (MRI) can also help to confirm a diagnosis of EDS.
Is Ehlers-Danlos a neurological disease?
Ehlers–Danlos syndrome (EDS) is a heterogeneous heritable connective tissue disorder with various neurological manifestations, including chronic pain. The neurological manifestations in EDS are often regarded as being caused by the associated musculoskeletal disorders or polyneuropathy.
What does EDS pain feel like?
I was asked recently to describe what my body feels with EDS. I described the feeling of being tenderized with a mallet all over my body. Not enough to break bones, but hard enough to leave bruises. This is my daily experience even with the aid of pain meds.
What medications should be avoided with EDS?
Official Answer. With Ehlers-Danlos syndrome (EDS), experts recommend avoiding drugs that increase your risk of bleeding—such as anticoagulants and antiplatelet agents—because those affected with EDS are at higher risk for bruising and injury.
What mimics Ehlers-Danlos syndrome?
Tnxb-/- mice showed progressive skin hyperextensibility, similar to individuals with Ehlers-Danlos syndrome. Biomechanical testing confirmed increased deformability and reduced tensile strength of their skin.
What supplements help Ehlers-Danlos?
We therefore hypothesize that the symptoms associated with Ehlers-Danlos syndrome may be successfully alleviated using a specific (and potentially synergistic) combination of nutritional supplements, comprising calcium, carnitine, coenzyme Q(10), glucosamine, magnesium, methyl sulphonyl methane, pycnogenol, silica, …