Rheumatoid arthritis (RA) is a systemic inflammatory disease mainly characterized by synovitis and joint destruction. Etiology of RA is unknown. Although the impact of genetic factors is obvious, the genetic basis is not sufficient to explain the triggering of the immune insult.
Regarding this, what are the four stages of rheumatoid arthritis?
Four Stages and Progression of Rheumatoid Arthritis. Rheumatoid arthritis (RA) affects different people in different ways. It can be mild, moderate, or severe, and symptoms vary from person to person.
: the physiology of abnormal states specifically : the functional changes that accompany a particular syndrome or disease.
In this way, what is rheumatoid arthritis scholarly?
Rheumatoid arthritis is an autoimmune inflammatory disease primarily characterized by synovitis which is accompanied by extra-articular organ involvement, such as interstitial pneumonia, in addition to clinical symptoms including pain, swelling, stiffness of multiple joints, fever, and malaise.
What is the etiological agent for rheumatoid arthritis?
Human parvovirus B19 as a causative agent for rheumatoid arthritis.
What is the main pathological event in rheumatoid arthritis?
Bone loss is a pathological hallmark of RA and manifests as localized, periarticular and systemic bone loss. Bone loss is the result of the induction of osteoclasts and the suppression of osteoblasts.
What is the pathophysiology of arthritis?
In rheumatoid arthritis, the body’s immune system attacks the lining of the joint capsule, a tough membrane that encloses all the joint parts. This lining (synovial membrane) becomes inflamed and swollen. The disease process can eventually destroy cartilage and bone within the joint.
What is the principle of rheumatoid arthritis?
Principle of the Rheumatoid Factor test
The rheumatoid factor is an anti-antibody. This can be detected in the laboratory by its ability to bind and form clumps with latex particles or red blood cells that contain human Immunoglobulin G (IgG).
Which cells have a major role in the pathophysiology of rheumatoid arthritis?
Among them, T cells (5) and macrophages (6) are recognized as two critical cellular components involved in RA. The essential role of T cells in the pathogenesis of RA has been validated, including studies on the infiltration of synovial T cells in inflammatory synovium of RA (7).