Pathophysiology of atherosclerosis
Hypercholesterolaemia is considered one of the main triggers of atherosclerosis. The increase in plasma cholesterol levels results in changes of the arterial endothelial permeability that allow the migration of lipids, especially LDL-C particles, into the arterial wall.
Herein, what are the 3 main causes of atherosclerosis?
Causes
- High blood pressure.
- High cholesterol.
- High triglycerides, a type of fat (lipid) in your blood.
- Smoking and other sources of tobacco.
- Insulin resistance, obesity or diabetes.
- Inflammation from an unknown cause or from diseases such as arthritis, lupus, psoriasis or inflammatory bowel disease.
Considering this, what is atherosclerosis give the etiology and pathogenesis of atherosclerosis? Atherosclerosis is a multifocal, smoldering, immunoinflammatory disease of medium-sized and large arteries fuelled by lipids. Endothelial cells, leukocytes, and intimal smooth muscle cells are the major players in the development of this disease.
In this manner, what is the pathophysiology of atherosclerosis quizlet?
– presence of focal thickenings (plaques) of the innermost layer (intima) of elastic and muscular arteries known as atheroschlerotic lesions. – when plaques form, the lumen of the artery becomes narrowed and there is less room for blood to flow through.